She starred when Officer Janice Licalsi in the television law drama NYPD Blue in 1993-1994 at the height of its popularity.

Within 1999, Brenneman became owner & executive producer, when well as starred in the television series Judging Amy. Brenneman portrays the divorced, lone mother working as a Personal Court Judge around Hartford, Connecticut. A indicate's construct was according to Brenneman's mother's real-life lives as a Superior Court Judge in the state of Connecticut. Judging Amy ran on CBS for six seasons & 138 episodes from either September 19, 1999 to May 3, 2005 to good ratings.

Brenneman is married to moving-picture show director Brad Silberling, with whom she has 2 tykes.